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Principal Scientist, Translational Oncology

Company: Recursion
Location: Salt Lake City
Posted on: May 16, 2022

Job Description:

Everything we do is in pursuit of changing lives. -
Rather than make a prediction on one or two products or indications, what if you could build a biological map that supports dozens or hundreds of indications? Every week at Recursion, we run 1.8 million+ experiments creating a library of more than one billion cellular images on the basis of that radically different approach to biotech. This is a revolutionary approach that we believe will reinvent drug discovery and development. -
What we've learned is that curing many human diseases takes more than sheer brains and ambition. It requires a willingness for people to push themselves and each other out of their comfort zones and kicking big ideas around with people far outside their "silo." We encourage biologists to sit with data scientists and clinical scientists and think beyond what already exists, to be willing to engage with new thinking and have deeper conversations about what could be. Every day we learn from and influence each other. Occasionally, we inspire one another.
To balance the push/pull of creative friction, we share the responsibility of caring for each other. We want to do our best work and invent the future together without conflict or eroding away our spirit. The idea that we care - for our patients, for our work and for each other is one of our core values. Alongside our other values of delivering, being bold with integrity, learning, and working as One Recursion, we have built a culture that lets people work at their best, sprinting towards new ideas knowing that there will be time for recovery. These values are more than posters and taglines. They are the concepts we discuss and question regularly because we work and live by them every single day. -
You'll be joining Recursion at an interesting time, both for the company and for the world. The global pandemic has reinforced in everyone's mind not only the importance of therapeutics, but also the critical value that accelerating every phase of drug discovery and development can provide. For most, the notion that "patients can't wait" is abstract; COVID-19 has made this concept all too real for millions, even billions, worldwide. -
It is an audacious goal, but it isn't a dream or science fiction. We're already doing it.
The Impact You'll Make
Recursion Pharmaceuticals is at the forefront of re-imaging drug discovery through the integration of automated cell biology, high-dimensional and diverse data sets, and sophisticated analytics. We are seeking a Senior or Principal Scientist with drug discovery experience in oncology and/or immuno-oncology to lead multiple programs through preclinical development to bring life-changing therapeutics to patients. As a Principal Scientist, you will:

  • Decode Recursion's map of cellular biology to identify novel targets for oncology
  • Leadin vitro target validation, MoA, and pharmacology for targets identified in oncology
  • Innovate approaches to realize and validate strategies for novel in vitro or in vivo oncology models
  • Mentor a team of Scientists in the use of new assay technologies for oncology
  • Collaborate with biologists, data scientists, computational oncologists, and chemists across the organization to successfully deliver programs.

    The Team You'll Join
    Reporting to the VP, Oncology, you will join a diverse, dynamic team of innovative scientists working to develop novel therapies for oncology. You will lead data-driven drug discovery projects in oncology by collaborating with in vitro and in vivo biology, chemistry, and data science team members. As our teams are small and nimble, we are excited by investigators with drive and ingenuity to develop and lead new programs.
    The Experience You'll Need

    • Training in Oncology translational sciences and completion of an advanced post-graduate degree (PhD) with 5+ years of small molecule drug discovery
    • Experience in scientific leadership and mentorship experience advancing small molecule oncology therapeutics programs from discovery to in vivo validation
    • Experience in scientific leadership and mentorship experience in design, execution and analysis of in-vitro MoA and small molecule pharmacology studies and fundamental understanding of state of the art molecular biology techniques (CRISPR/Cas9, single cell technologies)
    • Machine learning/data science experience is a plus
    • Experience in advancing candidates through IND enabling is a plus
    • Bold, passionate, and highly collaborative growth mindset


Keywords: Recursion, Salt Lake City , Principal Scientist, Translational Oncology, Healthcare , Salt Lake City, Utah

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